Monday, 25 October 2010

Digoxin Toxicity - Predisposing Factors


Digoxin Toxicity Predisposing Factors (System Related):
  • General - Old age
  • Cardiac - Myocardial ischaemia
  • Respiratory - Acute hypoxia
  • Hepatobiliary - Reduced hepatic clearance
  • Metabolic - Electrolyte disturbance, Hypokalaemia, Hypercalcaemia
  • Endocrine - Hypothyroidism
  • Renal - Reduced renal clearance, Renal insufficiency
  • Pharmacology - Drug interactions
Drug Interactions:
  • Amiodarone
  • Anticholinergic drugs
  • Captopril
  • Clarithromycin
  • Diltiazem
  • Erythromycin
  • Ibuprofen
  • Nifedipine
  • Quinidine
  • Verapamil
Image: Digoxin Molecule Wikipedia Public Domain

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