“He is a pink complexioned person, except when he has stood for a long time, when he may get pale and faint. His handshake is warm and dry. . . . He is thin because his appetite is modest; he never feels hunger pains and his stomach never rumbles. . . . As old age comes on he will suffer from retention of urine and impotence but frequency, precipitancy, and strangury will not worry him.”
Background:
- This description by Paton, in 1954, summarises the effects of pharmacologic blockade of ganglionic transmission.
- Hexamethonium blocks ganglionic nicotinic acetylcholine receptors.
- Hexamethonium thus causes dysfunction of the efferent sympathetic & parasympathetic pathways.
- Erectile dysfunction
- Impaired bladder emptying
- Orthostatic hypotension
- Saliva production decreased
- Sweating absence (anhidrosis)
- Tear production decreased
Reference:
Paton WD. Transmission and block in autonomic ganglia. Pharmacol Rev 1954;6:59-67
Image: from http://ridzuanzaidi.blogspot.com/
Tags: Anhidrosis - Autonomic Nervous System - Erectile Dysfunction - Hexamethonium - Hypotension - Man - Orthostatic Hypotension - Parasympathetic Nervous System - Sympathetic Nervous System - Sweating
Posted by Medicalchemy
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Posted by Medicalchemy
Medicalchemy Group: Images - Mnemonics - Anatomy - Cardiology - Dermatology - Drugs - Endocrinology - Gastroenterology - Genetics - Geriatrics - Gynecology-Haematology-Immunology- Infection - Metabolic Medicine - Nephrology - Neuroscience - Nutrition - Obstetrics - Oncology - Ophthalmology - Orthopaedics - Otolaryngology - Pathology-Pharmacology - Physiology- Psychiatry -Public Health - Respiratory - Surgery - Toxicology - Vascular.
